Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib)
نویسندگان
چکیده
منابع مشابه
Heterotopic Ossification after Spinal Cord Injury
From 1981 to 1986 we treated 413 patients for acute spinal-cord injuries. We reviewed 356 patients followed for a minimum of two years of whom 71 (20%) developed heterotopic ossification around one or more joints. Heterotopic ossification occurred more often in male patients (23%) than in female (10%), and was most frequent in the 20to 30-year age group. It was also more common after injuries o...
متن کاملHeterotopic ossification following traumatic brain injury and spinal cord injury.
Heterotopic ossification associated with neurologic injury, or neurogenic heterotopic ossification, tends to form at major synovial joints surrounded by spastic muscles. It is commonly associated with traumatic brain or spinal cord injury and with other causes of upper motor neuron lesions. Heterotopic ossification can result in a variety of complications, including nerve impingement, joint ank...
متن کاملNovel mouse model of spinal cord injury-induced heterotopic ossification.
Heterotopic ossification (HO) develops in about 20% to 30% of patients with spinal cord injury (SCI) and significantly impairs their rehabilitation. There is no effective prevention or treatment for this condition at this time. Our current understanding of its etiology and pathophysiology is limited partially due to the lack of clinically relevant animal models. In this study, we report a novel...
متن کاملRisk factors of heterotopic ossification in traumatic spinal cord injury.
OBJECTIVE Heterotopic ossification (HO) is a complication of the spinal cord injury (SCI). It can result in anchylosis, harming the rehabilitation and quality of life. Previous publications had not elucidated the relation between possible independent variables, the aim of this study. METHOD From 230 patients with SCI, admitted in 1998 at Hospital SARAH Brasilia, 33 with HO (14.3%; CI95% 10.1-...
متن کاملAssociation of α2-HS Glycoprotein with Neurogenic Heterotopic Ossification in Patients with Spinal Cord Injury
BACKGROUND The aim of this study was to explore the relationship between the α2-HS glycoprotein concentrations in serum and the occurrence of neurogenic heterotopic ossification (NHO) in patients with spinal cord injury (SCI). MATERIAL AND METHODS During the period between January 2011 and January 2012, 75 patients (67 male) with paraplegia caused by spinal cord injury were enrolled. The patien...
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ژورنال
عنوان ژورنال: Spinal Cord
سال: 2004
ISSN: 1362-4393,1476-5624
DOI: 10.1038/sj.sc.3101628